No. 1 New York Times bestselling author Chelsea Handler brings her Life Will Be the Death of Me stand-up comedy tour to Pittsburgh this weekend, with a Friday night show at the Byham Theater.

The tour comes on the heels of her recent return to stand-up following the success of her eponymous memoir that was released through Penguin Random House earlier this year, debuting at No. 1 on the New York Times Best Sellers list. Handler embarked on a sit-down comedy tour in support of the book and subsequently launched a limited series podcast through iHeartMedia.

Don’t miss your chance to see one of comedy’s reigning queens this weekend.