500 Sampsonia Way, North Side
412-231-3169 or www.mattress.org
A bastion of the local arts scene since 1977, this museum is dedicated to providing spaces for home-grown artists, as well as international talent. Housed in a literal former mattress factory in the architecturally charming Mexican War Streets, the provocative work will leave you thoughtful for hours.
2nd: BOOM Concepts, Garfield
3rd: Most Wanted Fine Art (now closed)